Journal article
Pancreatic cancer genomics: Where can the science take us?
JS Graham, NB Jamieson, R Rulach, SM Grimmond, DK Chang, AV Biankin
Clinical Genetics | Published : 2015
DOI: 10.1111/cge.12536
Abstract
The incidence of pancreatic ductal adenocarcinoma (PDAC) is steadily increasing and the annual death-to-incidence ratio approaches one. This is a figure that has not changed for several decades. Surgery remains the only chance of cure; however, only less than 20% of patients are amenable to operative resection. Despite successful surgical resection, the majority of the patients still succumb to recurrent metastatic disease. Therefore, there is an urgent need to develop novel therapeutic strategies and to better select patients for current therapies. In this review, we will discuss current management by highlighting the landmark clinical trials that have shaped current care. We will then disc..
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Grants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by Cancer Council NSW
Awarded by Cancer Institute NSW
Funding Acknowledgements
This work was supported by National Health and Medical Research Council of Australia (NHMRC; 631701, 535903, 427601), Queensland Government (NIRAP), University of Queensland, Institute for Molecular Bioscience, Australian Government: Department of Innovation, Industry, Science and Research (DIISR), Australian Cancer Research Foundation (ACRF), Cancer Council NSW: (SRP06-01, SRP11-01. ICGC), Cancer Institute NSW: (10/ECF/2-26; 06/ECF/1-24; 09/CDF/2-40; 07/CDF/1-03; 10/CRF/1-01, 08/RSA/1-15, 07/CDF/1-28, 10/CDF/2-26, 10/FRL/2-03, 06/RSA/1-05, 09/RIG/1-02, 10/TPG/1-04, 11/REG/1-10, 11/CDF/3-26), Garvan Institute of Medical Research, Avner Nahmani Pancreatic Cancer Research Foundation, R.T. Hall Trust, Petre Foundation, Philip Hemstritch Foundation, Gastroenterological Society of Australia (GESA), American Association for Cancer Research (AACR) Landon Foundation - INNOVATOR Award, Royal Australasian College of Surgeons (RACS), Royal Australasian College of Physicians (RACP), Royal College of Pathologists of Australasia (RCPA), and NHS Research Scotland.